KIF23 — Kinesin family member 23
KIF23 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KIF23's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitotic Spindle Cell cycle | ASPM, BUB1, CENPA, CENPE, CENPF, DLGAP5, GTSE1, HMMR +6 more | View in SCUBA |
About the gene
| Synonyms | KNSL5, MKLP-1, MKLP1 |
|---|---|
| Chromosome | 15: 69414246-69448427 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Motor protein |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.