Mitotic Spindle
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 15 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 15 genes have a known function matching the annotation |
Why this annotation
All 15 genes are canonical mitotic spindle assembly and kinetochore components. HMMR and TPX2 regulate Aurora A at the spindle; DLGAP5 (HURP) stabilizes kinetochore microtubules; SGO2 protects centromeric cohesion; ASPM regulates mitotic spindle poles; CENPE, NUF2, CENPF, CENPA are kinetochore/centromere proteins; KIF23 (MKLP1) and KIF14 are kinesins essential for cytokinesis; BUB1 is the spindle checkpoint kinase; GTSE1 regulates microtubule dynamics in late mitosis; PRR11 promotes G2/M; TUBA1C is a tubulin isoform enriched in dividing cells. Core coherence and uniform low pct positive (~4.6%) match a small cycling CD8 fraction. This module is neighbor to M29 and M33, together defining a coherent mitotic cell cycle neighborhood.
Genes
ASPM, BUB1, CENPA, CENPE, CENPF, DLGAP5, GTSE1, HMMR, KIF14, KIF23, NUF2, PRR11, SGO2, TPX2, TUBA1C
Most correlated modules
- G2/M Cell Cycle · correlation 0.98
- Mitosis & Cytokinesis · correlation 0.98
- Spindle Bipolarity Cytokinesis · correlation 0.95
- CDK1-Aurora Kinase Mitosis · correlation 0.95
- FOXM1-driven G2/M · correlation 0.95
- Mitotic Kinase Cascade · correlation 0.94
- S-phase Chromatin Replication · correlation 0.93
- G1/S Entry Checkpoint · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.