CENPE — Centromere protein E
CENPE belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CENPE's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitotic Spindle Cell cycle | ASPM, BUB1, CENPA, CENPF, DLGAP5, GTSE1, HMMR, KIF14 +6 more | View in SCUBA |
| Endothelial | Mitotic Spindle Cell cycle | ASPM, CCNB1, CDK1, CENPF, CKAP2, KIF20B, KNSTRN, LMNB1 +14 more | View in SCUBA |
| Gamma-delta T cells | Mitosis Execution Cell cycle | ASF1B, BUB1, CDCA8, CENPF, CKS1B, EZH2, MAD2L1, MKI67 +12 more | |
| Goblet cells | G2/M Cyclin Program Cell cycle | ARL6IP1, CCNB1, CCNB2, CDC20, CENPF, CEP55, DLGAP5, HMMR +5 more | View in SCUBA |
| Macrophages | Mitotic Spindle Cell cycle | ANLN, ASPM, AURKA, BIRC5, CCNA2, CCNB1, CCNB2, CDK1 +14 more | View in SCUBA |
About the gene
| Synonyms | KIF10, PPP1R61 |
|---|---|
| Chromosome | 4: 103105349-103198445 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Developmental protein, Motor protein |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules. The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated. Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends. Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized. Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules The stabilization of kinetochore- microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.