CENPA — Centromere protein A
CENPA belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CENPA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | G2/M Mitosis Cell cycle | AURKA, BUB1, CCDC34, CCNB1, CCNB2, CDC20, CDKN3, DLGAP5 +7 more | View in SCUBA |
| CD8⁺ T cells | Mitotic Spindle Cell cycle | ASPM, BUB1, CENPE, CENPF, DLGAP5, GTSE1, HMMR, KIF14 +6 more | View in SCUBA |
| Goblet cells | Mitotic Spindle Assembly Cell cycle | ARHGAP11A, AURKA, CDKN3, CKAP5, CKS2, FAM83D, KIF14, KNL1 +5 more | View in SCUBA |
About the gene
| Synonyms | CenH3, CENP-A |
|---|---|
| Chromosome | 2: 26764289-26801067 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Cell cycle, Cell division, Host-virus interaction, Mitosis |
Function
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well- ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.