HMMR — Hyaluronan mediated motility receptor
HMMR belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HMMR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Mitotic Spindle Cell cycle | CENPF, GTSE1, KIF11, KIF22, KIFC1, NCAPG, SGO1, SHCBP1 +3 more | View in SCUBA |
| CD8⁺ T cells | Mitotic Spindle Cell cycle | ASPM, BUB1, CENPA, CENPE, CENPF, DLGAP5, GTSE1, KIF14 +6 more | View in SCUBA |
| Goblet cells | G2/M Cyclin Program Cell cycle | ARL6IP1, CCNB1, CCNB2, CDC20, CENPE, CENPF, CEP55, DLGAP5 +5 more | View in SCUBA |
| Hematopoietic progenitor cells | Mitotic Spindle Cell cycle | BIRC5, CCNB2, CDC20, CDKN3, CEP55, DLGAP5, MKI67, TPX2 +1 more | |
| Macrophages | Mitotic Spindle Cell cycle | ANLN, ASPM, AURKA, BIRC5, CCNA2, CCNB1, CCNB2, CDK1 +14 more | View in SCUBA |
About the gene
| Synonyms | CD168, RHAMM |
|---|---|
| Chromosome | 5: 163460203-163491941 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | CD markers, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins |
Function
Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.