ASPM — Assembly factor for spindle microtubules
ASPM belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ASPM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitotic Spindle Cell cycle | BUB1, CENPA, CENPE, CENPF, DLGAP5, GTSE1, HMMR, KIF14 +6 more | View in SCUBA |
| Endothelial | Mitotic Spindle Cell cycle | CCNB1, CDK1, CENPE, CENPF, CKAP2, KIF20B, KNSTRN, LMNB1 +14 more | View in SCUBA |
| Hematopoietic progenitor cells | Mitotic Spindle Cell cycle | CDCA8, GTSE1, KIF15, KIF2C, KIF4A, NCAPG, NUSAP1, SPC25 +2 more | |
| Macrophages | Mitotic Spindle Cell cycle | ANLN, AURKA, BIRC5, CCNA2, CCNB1, CCNB2, CDK1, CDKN2C +14 more | View in SCUBA |
| Natural Killer cells | Mitotic Spindle Cell cycle | ARL6IP1, CENPF, CKS1B, KIF22, MKI67, NUSAP1, PTTG1, TACC3 +3 more | View in SCUBA |
About the gene
| Synonyms | ASP, Calmbp1, FLJ10517, FLJ10549, MCPH5 |
|---|---|
| Chromosome | 1: 197084121-197146694 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Calmodulin-binding |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex. May have a preferential role in regulating neurogenesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.