Nuclear Pore Organization
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 23 genes have a known function matching the annotation |
Why this annotation
Key hub genes include NUP210 and NUP155 (nuclear pore complex components), LBR (nuclear lamina/lamin B receptor), PDS5B (cohesin accessory factor), SMG7 (NMD), DHX8 and RBM25 (splicing), LARP1 (mRNA stability), and TAOK1 (kinase). The nuclear pore and envelope genes (NUP210, NUP155, LBR) represent the most coherent structural theme, with RNA processing genes as secondary. Moderate coherence reflects this mixed composition. In the context of neighbor modules M33 (chromatin remodeling) and M42 (splicing), this module captures nuclear envelope/pore organization as the complementary structural layer of nuclear homeostasis.
Genes
AIDA, DHX8, H4C6, LARP1, LBR, MPRIP, MTR, NNT, NUP155, NUP210, PDS5B, PHIP, PPT1, RBL1, RBM25, SFT2D2, SLC39A8, SMG7, SPTBN1, TAOK1, TTC3, ZFX, ZNF266
Most correlated modules
- Chromatin Remodeling · correlation 0.86
- DNA Damage Response · correlation 0.84
- Vesicular Trafficking · correlation 0.82
- Translation & Proteostasis · correlation 0.81
- Actin Cytoskeletal Regulation · correlation 0.78
- mRNA Splicing · correlation 0.77
- Post-transcriptional RNA Regulation · correlation 0.76
- mTOR-Exocyst Signaling · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.