LARP6 — La ribonucleoprotein 6, translational regulator
LARP6 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LARP6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Angiogenic Metabolic Adaptation Endothelial cell development | BLVRB, DAAM1, HMGN3, PCBP2, POLE4, PRKAG2, PRPSAP1, PRR5 +2 more | View in SCUBA |
About the gene
| Synonyms | acheron, FLJ11196 |
|---|---|
| Chromosome | 15: 70829130-70854157 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | Translation regulation |
Function
Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.