HMGN3 — High mobility group nucleosomal binding domain 3
HMGN3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HMGN3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Angiogenic Metabolic Adaptation Endothelial cell development | BLVRB, DAAM1, LARP6, PCBP2, POLE4, PRKAG2, PRPSAP1, PRR5 +2 more | View in SCUBA |
| Glial cells | ER-Mitochondria Housekeeping Mitochondrial & OxPhos | CNN3, COX6C, LDHB, NDUFB5, NDUFS8, PDIA3, TMBIM4, TMBIM6 +2 more | View in SCUBA |
| Innate lymphoid cells | ILC-1 identity Differentiation | ABRACL, BLOC1S1, C19orf53, CD52, DAD1, FUCA2, GMFG, ISCU +20 more | View in SCUBA |
| Lymphatic endothelial | Oxidative Stress Protection Stress | ALDH2, ANAPC16, BCL7C, CAVIN2, CCL21, CD320, CRACR2B, FXYD6 +10 more | View in SCUBA |
| Macrophages | Complex I / NADH Dehydrogenase Mitochondrial & OxPhos | AHCY, ANP32A, ANTKMT, APEX1, ARL2, ATIC, ATP5F1A, ATP5ME +31 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Identity T cell maturation | ARPC1B, BLOC1S1, C4orf3, CD3D, CHKB, CPNE1, DDX39B, MARCHF9 +9 more | |
| Smooth muscle cells | Post-translational regulators Housekeeping | ANXA11, BAG1, BANF1, CALM3, CAMTA1, ERH, MYO1C, NENF +6 more | View in SCUBA |
About the gene
| Synonyms | TRIP7 |
|---|---|
| Chromosome | 6: 79201245-79234689 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Chromatin regulator, DNA-binding |
Function
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.