Angiogenic Metabolic Adaptation
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 11 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include PRKAG2 (AMP-activated protein kinase gamma subunit, energy sensing), VEGFB (vascular endothelial growth factor B, angiogenesis/endothelial survival), DAAM1 (formin involved in actin cytoskeleton/Wnt signaling), LARP6 (RNA-binding protein regulating collagen mRNA), BLVRB (biliverdin reductase B, oxidoreductase), PRR5 (mTORC2 component), and PCBP2 (RNA-binding). The module is significantly upregulated in both UC and CD inflammation and reverses in remission. VEGFB and PRKAG2 point to metabolic/angiogenic endothelial adaptation. LARP6 is known to regulate collagen synthesis. The combination of VEGFB, PRKAG2 (energy sensing), PRR5 (mTORC2), and DAAM1 suggests an angiogenic/metabolic adaptation program in inflamed endothelium. The inflammation-responsive pattern and VEGFB hub support an angiogenic response label.
Genes
BLVRB, DAAM1, HMGN3, LARP6, PCBP2, POLE4, PRKAG2, PRPSAP1, PRR5, RALGAPA2, VEGFB
Most correlated modules
- Inflammatory Stress Response · correlation 0.93
- Oxidative Phosphorylation · correlation 0.87
- Translation Elongation · correlation 0.85
- Lysosomal Autophagy Program · correlation 0.82
- Leukocyte Recruitment Signaling · correlation 0.82
- Venous EC Identity · correlation 0.80
- IL33 Alarmin Signaling · correlation 0.79
- Venular Inflammatory Activation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.