PCBP2 — Poly(rC) binding protein 2
PCBP2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PCBP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Angiogenic Metabolic Adaptation Endothelial cell development | BLVRB, DAAM1, HMGN3, LARP6, POLE4, PRKAG2, PRPSAP1, PRR5 +2 more | View in SCUBA |
| Innate lymphoid cells | Cellular Metabolic Maintenance Metabolism | ADIPOR1, APH1A, ARF5, BCAP31, CLIC1, CSNK2B, CYB5R3, DHPS +13 more | View in SCUBA |
| Macrophages | Autophagy Vesicular Trafficking Vesicular traficking | ACTR2, AHCYL1, ALKBH5, BECN1, BICD2, CAP1, CAPRIN1, COLGALT1 +32 more | View in SCUBA |
| Mucosal-associated invariant T cell | PI3K MAPK Signaling TCR Signaling | AKT1, APH1A, BRD4, CALM2, CMTM3, DAZAP1, GNAS, GRK2 +11 more | |
| Pericytes | RNA Splicing Processing Housekeeping | ENY2, PCBP1, PLSCR1, RBM8A, RTN4, SLC3A2, SRSF4, WAC | View in SCUBA |
| Smooth muscle cells | mRNA Splicing Factors RNA processing & translation | ATF4, BEX3, CLIC4, COX20, HNRNPA0, NAP1L1, NDUFA6, NME4 +7 more | View in SCUBA |
About the gene
| Synonyms | hnRNP-E2, HNRNPE2, HNRPE2 |
|---|---|
| Chromosome | 12: 53452102-53481162 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding, Ribonucleoprotein, RNA-binding |
| Biological process | Antiviral defense, Host-virus interaction, Immunity, Innate immunity, Viral RNA replication |
Function
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Also binds poly(rU). Acts as a negative regulator of antiviral signaling. Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation. Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid- like droplets in which CGAS is activated. Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.