POLE4 — DNA polymerase epsilon 4, accessory subunit
POLE4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POLE4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Angiogenic Metabolic Adaptation Endothelial cell development | BLVRB, DAAM1, HMGN3, LARP6, PCBP2, PRKAG2, PRPSAP1, PRR5 +2 more | View in SCUBA |
| Fibroblasts | Focal Adhesion ECM Migration & adhesion | ACTN1, CLIC4, COL4A1, COL4A2, MPRIP, MRPL33, MYL6, NDUFA4 +6 more | View in SCUBA |
About the gene
| Synonyms | p12 |
|---|---|
| Chromosome | 2: 74958643-74970128 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.