PRR5 — Proline rich 5
PRR5 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRR5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Gamma-delta T cell Cell contamination | ABHD15, ANKRD28, APOBR, CLIC3, CLIC5, EGLN3, ELOVL6, GLO1 +9 more | View in SCUBA |
| Endothelial | Angiogenic Metabolic Adaptation Endothelial cell development | BLVRB, DAAM1, HMGN3, LARP6, PCBP2, POLE4, PRKAG2, PRPSAP1 +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | MAIT Tissue Residence Tissue residence | ANAPC16, ARHGDIB, ATP5IF1, CD3E, CD53, CD99, CTSD, CXCR6 +7 more | |
| Natural Killer cells | Gut-Homing NK Maturation Gut residency | ANXA2, BIN1, DHRS7, HECA, IFI27L2, ITGB7, KLF9, LGALS1 +5 more | View in SCUBA |
About the gene
| Synonyms | FLJ20185k, PP610, Protor-1 |
|---|---|
| Chromosome | 22: 44668547-44737681 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell cycle |
Function
Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.