SCUBA

DAAM1 — Dishevelled associated activator of morphogenesis 1

DAAM1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DAAM1's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsB-cell activation signaling
B cell maturation		CD180, CYB561A3, ETS1, LIMD2, STX7, TERF2IP, UCP2, ZNF106View in SCUBA
EndothelialAngiogenic Metabolic Adaptation
Endothelial cell development		BLVRB, HMGN3, LARP6, PCBP2, POLE4, PRKAG2, PRPSAP1, PRR5 +2 moreView in SCUBA
FibroblastsComplement-producing Fibroblast
Inflammatory		ANK2, C3, CLSTN3, CYP7B1, DHRS3, GUCY1A1, GUCY1B1, LPAR1 +8 moreView in SCUBA
Lymphatic endothelialActin Cytoskeletal Scaffold
Cytoskeletal		CCDC102B, CCND3, DPYSL3, EPB41L2, GOLM2, GPATCH2, KLHL4, PPFIBP1 +1 moreView in SCUBA

About the gene

SynonymsKIAA0666
Chromosome14: 59188646-59371405
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins
Molecular functionActin-binding
Biological processWnt signaling pathway

Function

Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.