LIPH — Lipase H
LIPH belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LIPH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Basement Membrane Remodeling migration & adhesion | AHNAK, CD55, CYP3A5, F3, GPRC5A, LAMA3, LAMB3, LAMC2 +7 more | View in SCUBA |
About the gene
| Synonyms | LPDLR, mPA-PLA1, mPA-PLA1alpha, PLA1B |
|---|---|
| Chromosome | 3: 185506262-185552588 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Heparin-binding, Hydrolase |
| Biological process | Lipid degradation, Lipid metabolism |
Function
Hydrolyzes specifically phosphatidic acid (PA) to produce 2- acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.