GPRC5A — G protein-coupled receptor class C group 5 member A
GPRC5A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GPRC5A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | EGFR wound response Epithelial development | CLDN4, DDX60L, ERRFI1, KLF6, SNX9, STOM | View in SCUBA |
| Goblet cells | Basement Membrane Remodeling migration & adhesion | AHNAK, CD55, CYP3A5, F3, LAMA3, LAMB3, LAMC2, LIPH +7 more | View in SCUBA |
| Monocytes | Myeloid Epigenetic Regulation Developmental | CYRIA, H2AC25, MN1, MTHFD1L, PCGF5, PDE2A, PPP1R14B, RAPH1 +1 more | View in SCUBA |
About the gene
| Synonyms | PEIG-1, RAI3, RAIG1, TIG1 |
|---|---|
| Chromosome | 12: 12891559-12917937 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.