F3 — Coagulation factor III, tissue factor
F3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
F3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Procoagulant TGF-β Response Inflammation | CITED4, CSF3, EHD1, LAMC1, LIPG, MED24, PLEKHO1, PMEPA1 +7 more | View in SCUBA |
| Fibroblasts | WNT-modulating Fibroblast Developmental | CIB2, COL4A5, DMKN, FIP1L1, FRZB, GPSM3, HSD17B2, INSC +9 more | View in SCUBA |
| Goblet cells | Basement Membrane Remodeling migration & adhesion | AHNAK, CD55, CYP3A5, GPRC5A, LAMA3, LAMB3, LAMC2, LIPH +7 more | View in SCUBA |
| Lymphatic endothelial | NRF2 Oxidative Stress Stress | ATP1B3, GCLM, GRPEL1, HMOX1, PLIN2, SLC3A2, TXNRD1 | View in SCUBA |
| Monocytes | NLRP3 Inflammasome Activation Innate immunity | ACSL1, BASP1, CCDC71L, CCL20, EREG, FAM107B, LRG1, NLRP3 +3 more | View in SCUBA |
| Pericytes | BMP-Stromal Signaling Developmental | BMP4, CXCL14, MMP2, NBL1, PDGFRA, POSTN, TMEM176A, TMEM176B | View in SCUBA |
| Smooth muscle cells | Neural Adhesion Program Development | CHL1, CNTN4, DSEL, EMID1, IGFBP3, MATN2, SSC5D, STMN2 +1 more | View in SCUBA |
About the gene
| Synonyms | CD142, TF |
|---|---|
| Chromosome | 1: 94529173-94541759 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters |
| Biological process | Blood coagulation, Hemostasis |
Function
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.