LAMA3 — Laminin subunit alpha 3
LAMA3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LAMA3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | JUN stress response Stress | FOXO3, H1-2, H2AC6, JUN, LAMB3, PTPRB, ZNF292 | View in SCUBA |
| Goblet cells | Basement Membrane Remodeling migration & adhesion | AHNAK, CD55, CYP3A5, F3, GPRC5A, LAMB3, LAMC2, LIPH +7 more | View in SCUBA |
| Smooth muscle cells | Capillary Pericyte Development | ADAP2, ADRA2A, ANKRD29, CCL8, CNGA1, ENPEP, EPHA2, EPS8L1 +10 more | View in SCUBA |
About the gene
| Synonyms | BM600-150kDa, epiligrin, kalinin-165kDa, LAMNA, nicein-150kDa |
|---|---|
| Chromosome | 18: 23689453-23956222 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.