Basement Membrane Remodeling
Gene co-expression module in Goblet cells
| Category | migration & adhesion |
|---|---|
| Genes | 16 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 16 genes have a known function matching the annotation |
Why this annotation
LAMC2, LAMA3, LAMB3 encode the three chains of laminin-332, a basement membrane complex classically induced during epithelial wound healing, migration, and EMT-adjacent remodeling. PLAUR (uPAR) and F3 (tissue factor) add invasion/matrix remodeling and hemostatic components. SERPINB5 (maspin) is a serine protease inhibitor linked to epithelial remodeling. CD55 protects from complement. CYP3A5 marks stress-adapted epithelium. TM4SF1 and GPRC5A are epithelial remodeling markers. Upregulated in UC/CD inflammation. The laminin-332 triad as co-expressed hub genes is the defining signature of basement membrane remodeling in wounded/inflamed epithelium.
Genes
AHNAK, CD55, CYP3A5, F3, GPRC5A, LAMA3, LAMB3, LAMC2, LIPH, LMO7, PLAUR, PMP22, RASEF, SERPINB5, SERPINB6, TM4SF1
Most correlated modules
- EGF-Driven Wound Repair · correlation 0.85
- Actin Cytoskeletal Remodeling · correlation 0.80
- Inflammatory goblet response · correlation 0.78
- Stress Survival Response · correlation 0.74
- S100 Calcium Signaling · correlation 0.71
- Hypoxia Metabolic Stress · correlation 0.69
- Mucosal Antibacterial Defense · correlation 0.67
- DUOX2 Epithelial Inflammation · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.