CYP3A5 — Cytochrome P450 family 3 subfamily A member 5
CYP3A5 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CYP3A5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Enterocyte fatty-acid catabolism Lipid metabolism | ACOX1, ACSL5, GDA, MIA2, MUC3A, OGDH, RIOK3 | View in SCUBA |
| Goblet cells | Basement Membrane Remodeling migration & adhesion | AHNAK, CD55, F3, GPRC5A, LAMA3, LAMB3, LAMC2, LIPH +7 more | View in SCUBA |
About the gene
| Synonyms | CP35, P450PCN3, PCN3 |
|---|---|
| Chromosome | 7: 99648194-99679998 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Monooxygenase, Oxidoreductase |
| Biological process | Lipid metabolism, Steroid metabolism |
Function
A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of catechol estrogens from 17beta- estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2. Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione. Catalyzes the oxidative conversion of all-trans- retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance. Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.