MECP2 — Methyl-CpG binding protein 2
MECP2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MECP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | gd T Cell Identity T cell maturation | AKAP17A, CNNM3, GALNT11, KCNA3, PIEZO1, PLXNC1, RASGEF1A, RERE +6 more | |
| Macrophages | Transcriptional Repression Housekeeping | AKAP8, ANKRD11, ARIH2, BACH1, CCNT2, CDK13, CEP95, CSNK1D +23 more | View in SCUBA |
About the gene
| Synonyms | MRX16, MRX79, RTT |
|---|---|
| Chromosome | X: 154021573-154137103 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.