gd T Cell Identity
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
ZNF831 and RERE are chromatin-associated zinc finger proteins involved in transcriptional regulation. MECP2 is a methyl-CpG binding chromatin regulator. SH2D1A (SAP) is a key signaling adaptor expressed in NKT and gd T cells regulating cytotoxicity and co-stimulation. KCNA3 encodes Kv1.3, a voltage-gated potassium channel critical for T cell activation. PIEZO1 is a mechanosensitive ion channel involved in T cell activation thresholds. PLXNC1 is a semaphorin receptor involved in immune cell migration and activation. SIPA1 is a Rap1 GTPase-activating protein regulating T cell adhesion. SYNM (synemin) is an intermediate filament protein. GALNT11 and AKAP17A have regulatory roles. The module combines chromatin regulation with gd/NKT-specific activation machinery.
Genes
AKAP17A, CNNM3, GALNT11, KCNA3, MECP2, PIEZO1, PLXNC1, RASGEF1A, RERE, SBF2, SH2D1A, SIPA1, SPART, SYNM, ZNF831
Most correlated modules
- Innate Stress Signaling · correlation 0.78
- ER Protein Translocation · correlation 0.74
- EOMES Effector Program · correlation 0.70
- T Cell Development · correlation 0.68
- T cell Identity Signaling · correlation 0.68
- Naive T cell quiescence · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.