ARIH2 — Ariadne RBR E3 ubiquitin protein ligase 2
ARIH2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARIH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB regulation TCR/AP1/NFKb pathway | CD58, CYLD, DAD1, DERL1, EED, ELOVL5, NFAT5, OTULIN +9 more | View in SCUBA |
| Gamma-delta T cells | Hypoxia Stress Response Stress | BNIP2, C9orf78, CHD4, FBXO7, HIF1A, HNRNPH1, JADE1, KIF21B +16 more | |
| Macrophages | Transcriptional Repression Housekeeping | AKAP8, ANKRD11, BACH1, CCNT2, CDK13, CEP95, CSNK1D, FNBP4 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB RNA Regulation RNA processing & translation | ATP1A1, BCLAF1, BNIP2, CALR, COG3, DDX6, EIF4G2, EIF4H +14 more |
About the gene
| Synonyms | TRIAD1 |
|---|---|
| Chromosome | 3: 48918821-48986382 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets. The initial ubiquitin is then elongated. E3 ubiquitin- protein ligase activity is activated upon binding to neddylated form of the cullin-5 (CUL5) component of the ECS complex. Together with the ECS(ASB9) complex, catalyzes ubiquitination of CKB. Promotes ubiquitination of DCUN1D1. Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis. (Microbial infection) Following infection by HIV-1 virus, acts together with a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, to catalyze ubiquitination and degradation of APOBEC3F and APOBEC3G
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.