KCNA3 — Potassium voltage-gated channel subfamily A member 3
KCNA3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KCNA3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | gd T Cell Identity T cell maturation | AKAP17A, CNNM3, GALNT11, MECP2, PIEZO1, PLXNC1, RASGEF1A, RERE +6 more | |
| Mucosal-associated invariant T cell | T cell Homeostasis T cell maturation | APOL6, CD40LG, CNDP2, FAM118A, FCMR, GPR171, IFIH1, IL7R +19 more |
About the gene
| Synonyms | HLK3, HPCN3, Kv1.3, MK3 |
|---|---|
| Chromosome | 1: 110653560-110674940 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels |
| Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
| Biological process | Ion transport, Potassium transport, Transport |
Function
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Lacks voltage-gated potassium channel activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.