Transcriptional Repression
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 32 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 32 genes have a known function matching the annotation |
Why this annotation
Hub genes include GON4L (transcriptional repressor), HECTD1 (HECT E3 ubiquitin ligase), ANKRD11 (chromatin/transcriptional corepressor), SP3 (Sp/KLF transcription factor), BACH1 (BTB-basic leucine zipper transcriptional repressor — key macrophage regulator of heme oxygenase-1 and inflammatory gene repression), SUPT6H (transcription elongation factor), TRIM33 (E3 ligase/TGF-β signaling repressor), SPEN (SHARP transcriptional repressor), MECP2 (methyl-CpG binding transcriptional repressor), CCNT2 (Cyclin T2, CDK9/P-TEFb elongation complex). SSH1 (slingshot cofilin phosphatase) and WHAMM (WASH/WAVE actin nucleation) add cytoskeletal components. The dominant theme is transcriptional repression, with BACH1 being particularly notable in macrophage biology for repressing HO-1 and modulating inflammatory responses. The module likely reflects a transcriptional repressor program active in monocyte-derived macrophages.
Genes
AKAP8, ANKRD11, ARIH2, BACH1, CCNT2, CDK13, CEP95, CSNK1D, FNBP4, GON4L, GPCPD1, HECTD1, KHDC4, KIAA0232, MAP3K8, MECP2, MGRN1, MOB3A, MYO9B, MYSM1, NPLOC4, SFSWAP, SP3, SPAG9, SPEN, SSH1, STK4, SUPT6H, TRIM33, TTC19, UPF2, WHAMM
Most correlated modules
- mRNA Splicing Processing · correlation 0.97
- Ubiquitin-Proteasome Regulation · correlation 0.97
- Epigenetic Remodeling · correlation 0.96
- Autophagy Vesicle Trafficking · correlation 0.95
- Microtubule Organization · correlation 0.95
- Chromatin Regulatory Genes · correlation 0.95
- RNA Processing Housekeeping · correlation 0.95
- NF-κB AP-1 Signaling · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.