RERE — Arginine-glutamic acid dipeptide repeats
RERE belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RERE's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR signaling/maturation B cell maturation | ATP6V0A1, BCL11A, CAMK2D, CD22, CLEC2D, DDHD1, DGKD, IL4R +9 more | View in SCUBA |
| Gamma-delta T cells | gd T Cell Identity T cell maturation | AKAP17A, CNNM3, GALNT11, KCNA3, MECP2, PIEZO1, PLXNC1, RASGEF1A +6 more | |
| Goblet cells | Chromatin Remodeling chromatin regulation & transcription | BAZ2B, BPTF, GTF2I, INSR, MYO10, PDZD8, TOP2B, ZKSCAN1 | View in SCUBA |
| Hematopoietic progenitor cells | HOX HSC Program Stemness | ADGRE2, AFF1, ARHGAP25, HOXA3, HOXA6, HOXA9, JAML, LPIN1 +3 more | |
| Macrophages | Ubiquitin Proteasome Regulation Housekeeping | ARIH1, BTAF1, CLASP2, DENND4A, DYRK1A, FBXO11, FBXW7, GATAD2B +8 more | View in SCUBA |
| Mucosal-associated invariant T cell | Immune Synapse Signaling TCR Signaling | APC, ARHGAP26, ASXL2, CD46, CPSF2, DOCK8, EEA1, EIF4G3 +21 more |
About the gene
| Synonyms | ARG, ARP, ATN1L, ATN2, DNB1, KIAA0458 |
|---|---|
| Chromosome | 1: 8352397-8848921 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Developmental protein, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.