NDC1 — NDC1 transmembrane nucleoporin
NDC1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NDC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Centrosome & DNA Repair Cell cycle | ANKRD13A, BRCA2, CASP2, CBX5, CCDC14, CEP152, CEP78, CKAP5 +34 more | View in SCUBA |
About the gene
| Synonyms | FLJ10407, NET3, TMEM48 |
|---|---|
| Chromosome | 1: 53765478-53838463 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | mRNA transport, Protein transport, Translocation, Transport |
Function
Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.