CEP152 — Centrosomal protein 152
CEP152 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CEP152's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | S-phase Replication Cell cycle | ATAD2, E2F7, E2F8, ESCO2, FAM111A, NCAPD3, POLQ, STIL | View in SCUBA |
| Macrophages | Centrosome & DNA Repair Cell cycle | ANKRD13A, BRCA2, CASP2, CBX5, CCDC14, CEP78, CKAP5, CSE1L +34 more | View in SCUBA |
About the gene
| Synonyms | KIAA0912, MCPH9, SCKL5 |
|---|---|
| Chromosome | 15: 48712928-48811146 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cilium biogenesis/degradation |
Function
Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation. Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.