Centrosome & DNA Repair
Gene co-expression module in Macrophages
| Category | Cell cycle |
|---|---|
| Genes | 43 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 15 of 43 genes have a known function matching the annotation |
Why this annotation
CEP152 and CEP78 are centriole biogenesis factors; TUBGCP3 is a γ-tubulin ring complex component; MPHOSPH9 is a centrosome protein. Together these define a centrosome duplication program. BRCA2, TOPBP1, RFWD3, USP1, and PRKDC (DNA-PK) are DNA damage response/homologous recombination factors active during S/G2. FAM111A is a replication fork protection factor. NUP107 is a nuclear pore component involved in kinetochore assembly. NSD2 is a histone H3K36 methyltransferase. This module links centrosome biogenesis with DNA damage checkpoint signaling in proliferating macrophages.
Genes
ANKRD13A, BRCA2, CASP2, CBX5, CCDC14, CEP152, CEP78, CKAP5, CSE1L, EZH2, FAM111A, GAS2L3, GMPS, IPO5, KDM1A, MASTL, MCMBP, MPHOSPH9, MRE11, NAP1L4, NASP, NCAPD3, NDC1, NSD2, NUP107, NUP155, NUP160, POLD3, PRKDC, PSIP1, QSER1, RANGAP1, RCC2, RFWD3, RNF138, SF3B3, SMC6, TOPBP1, TRIM26, TTF2, TUBGCP3, USP1, XPO1
Most correlated modules
- DNA Replication Metabolism · correlation 0.94
- G1/S Transition · correlation 0.92
- Ribosome Biogenesis · correlation 0.90
- Replication Chromatin Assembly · correlation 0.89
- Mitotic Spindle Assembly · correlation 0.83
- Mitotic Chromosome Condensation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.