BRCA2 — BRCA2 DNA repair associated
BRCA2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BRCA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | S-phase Chromatin Replication Cell cycle | ANP32E, CKAP2, HDGF, HP1BP3, LBR, MIS18BP1, NSD2, NUCKS1 +4 more | View in SCUBA |
| Endothelial | S-phase Proliferation Cell cycle | ATAD2, ATAD5, BRCA1, CENPH, CENPK, CENPU, DHFR, EZH2 +11 more | View in SCUBA |
| Gamma-delta T cells | S-phase Replication Cell cycle | ATAD2, ATAD5, CDT1, CENPH, CENPM, CENPU, CLSPN, DHFR +13 more | |
| Goblet cells | Replication Fork Checkpoint Cell cycle | ATAD2, CENPM, CLSPN, DNAJC9, FANCI, LIG1, PKMYT1, RRM1 | View in SCUBA |
| Hematopoietic progenitor cells | S-phase Progression Cell cycle | ATAD2, ATAD5, DNMT1, FANCI, LMNB1, RRM1, SMC2, TMPO +1 more | |
| Macrophages | Centrosome & DNA Repair Cell cycle | ANKRD13A, CASP2, CBX5, CCDC14, CEP152, CEP78, CKAP5, CSE1L +34 more | View in SCUBA |
About the gene
| Synonyms | BRCC2, FACD, FAD, FAD1, FANCD, FANCD1, XRCC11 |
|---|---|
| Chromosome | 13: 32315086-32400268 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Cell cycle, DNA damage, DNA recombination, DNA repair |
Function
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.