CASP2 — Caspase 2
CASP2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CASP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mRNA Splicing RNA processing & translation | ACTB, ACTG1, ACTL6A, ACTR3, AK2, BRD8, CCDC14, CCT5 +13 more | |
| Macrophages | Centrosome & DNA Repair Cell cycle | ANKRD13A, BRCA2, CBX5, CCDC14, CEP152, CEP78, CKAP5, CSE1L +34 more | View in SCUBA |
About the gene
| Synonyms | ICH1, MGC2181, NEDD2, PPP1R57 |
|---|---|
| Chromosome | 7: 143288215-143307696 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, Thiol protease |
| Biological process | Apoptosis |
Function
Is a regulator of the cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress. Acts as a positive regulator of apoptosis. Acts as a negative regulator of apoptosis. May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.