NRROS — Negative regulator of reactive oxygen species
NRROS belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NRROS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | TNF/NF-kB response BCR/AP1/NFKb pathway | ADGRE5, ATF3, BHLHE40, CHD1, CMTM6, CYLD, DUSP5, FMNL1 +7 more | View in SCUBA |
About the gene
| Synonyms | ELLP3030, GARPL1, LRRC33, MGC50789, UNQ3030 |
|---|---|
| Chromosome | 3: 196639694-196662004 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Predicted membrane proteins |
| Molecular function | Growth factor binding |
Function
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (By similarity). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF- beta-1 (By similarity). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS (By similarity). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.