ATF3 — Activating transcription factor 3

ATF3 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ATF3's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	TNF/NF-kB response BCR/AP1/NFKb pathway	ADGRE5, BHLHE40, CHD1, CMTM6, CYLD, DUSP5, FMNL1, IRF2BP2 +7 more	View in SCUBA
CD4⁺ T cells	NF-kB Feedback Response TCR/AP1/NFKb pathway	ADGRE5, ARL5B, CSRNP1, NFKBIZ, PPP1R15B, RASGEF1B, TIPARP, TNFAIP3 +2 more	View in SCUBA
CD8⁺ T cells	Immediate Early Response Stress	ARRDC3, CLK1, EIF4A2, EIF5, GADD45B, IER5, JUN, KLF6 +6 more	View in SCUBA
Endothelial	Integrated Stress Response Stress	ARL5B, CCNL1, CD83, CDKN1A, DDIT3, ICAM4, IRF1, KDM6B +3 more	View in SCUBA
Fibroblasts	NF-κB Immediate Early Inflammatory	DNAJA1, DUSP1, HLA-E, HSPA8, IRF1, MAFF, NFKBIA, NFKBIZ +4 more	View in SCUBA
Gamma-delta T cells	Activation Stress Response Stress	ARHGAP9, ARHGEF12, ATP6V0A2, GALNT6, GPR18, HIC1, HMCES, HMGCR +12 more
Glial cells	Integrated Stress Response Stress	CCNL1, DNAJA1, DUSP1, HSPA8, HSPH1, KLF4, MAFF, NR4A1 +2 more	View in SCUBA
Goblet cells	NF-κB Stress Response Stress	CCNL1, EGR3, IER3, MAFF, MYADM, NFKBIA, NR4A1, RHOB +1 more	View in SCUBA
Innate lymphoid cells	Immediate Early Response activation	BRD2, BTG2, CCNL1, DDX3X, DNAJA1, EGR1, EIF4A3, EIF5 +8 more	View in SCUBA
Lymphatic endothelial	Integrated Stress Response Stress	CSRNP1, DDIT3, DNAJA1, EIF4A2, HSP90AB1, PPP1R15A, RSRC2, SERTAD1 +2 more	View in SCUBA
Macrophages	Early response genes Inflammatory	BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4, DUSP1 +39 more	View in SCUBA
Monocytes	Inflammatory Stress Response Stress	ARL5B, CCRL2, CD83, DUSP10, IL1B, NFE2L2, RASGEF1B, SGK1 +2 more	View in SCUBA
Mucosal-associated invariant T cell	TCR-Induced Early Response TCR Signaling	EGR1, GLA, HMGCS1, IER3, NR4A1, NUP58, PPP1R15B, RHOB +3 more
Smooth muscle cells	Immediate Early Response Stress	BTG1, BTG2, CDKN1A, EGR1, FOS, GADD45B, HES1, IER2 +7 more	View in SCUBA

About the gene

Chromosome	1: 212565334-212620777
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Function

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Activates transcription presumably by sequestering inhibitory cofactors away from the promoters. Stress-induced isoform, counteracts the transcriptional repression of isoform 1

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.