CMTM6 — CKLF like MARVEL transmembrane domain containing 6
CMTM6 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CMTM6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | TNF/NF-kB response BCR/AP1/NFKb pathway | ADGRE5, ATF3, BHLHE40, CHD1, CYLD, DUSP5, FMNL1, IRF2BP2 +7 more | View in SCUBA |
| CD4⁺ T cells | TCR Complex Activation TCR/AP1/NFKb pathway | ABHD17A, ACTR3, C1GALT1, CD2, CD3D, CD3E, CD3G, CD81 +14 more | View in SCUBA |
| Fibroblasts | Actin Cytoskeleton Cytoskeletal | ACTB, CAPZA2, CFL1, COX8A, KIF5B, MORF4L2, NDUFS5, PCBP1 +6 more | View in SCUBA |
| Goblet cells | Ubiquitin Protein Homeostasis Housekeeping | ARPC2, BZW1, CSNK1A1, DAP, EMP2, GNAI3, KIF5B, MORF4L1 +6 more | View in SCUBA |
| Innate lymphoid cells | Antigen Processing MHC-I Immune regulation | GUK1, IL2RB, IL4R, MYL12A, PAXX, PSMA5, PSMB8, PSMB9 +8 more | View in SCUBA |
| Macrophages | ER Membrane Homeostasis Housekeeping | ATP6V1A, BNIP2, CANX, CAPZA1, CD164, COPB1, EXOC5, GFM1 +18 more | View in SCUBA |
About the gene
| Synonyms | CKLFSF6, FLJ20396 |
|---|---|
| Chromosome | 3: 32481312-32502852 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Transport |
Function
Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.