NRXN1 — Neurexin 1
NRXN1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NRXN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Neural Migration Scaffold Cytoskeletal | ABLIM1, ALCAM, ANK3, CAB39L, GAS2L3, GFRA3, IQGAP2, RELN +1 more | View in SCUBA |
About the gene
| Synonyms | Hs.22998, KIAA0578 |
|---|---|
| Chromosome | 2: 49918503-51225575 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Angiogenesis, Cell adhesion |
Function
Neuronal cell surface protein involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins (By similarity). Plays a role in formation of synaptic junctions (By similarity). Functions as part of a trans-synaptic complex by binding to cerebellins and postsynaptic GRID1. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2- GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.