RELN — Reelin
RELN belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RELN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Neural Migration Scaffold Cytoskeletal | ABLIM1, ALCAM, ANK3, CAB39L, GAS2L3, GFRA3, IQGAP2, NRXN1 +1 more | View in SCUBA |
About the gene
| Synonyms | PRO1598, RL |
|---|---|
| Chromosome | 7: 103471381-103989658 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Developmental protein, Hydrolase, Protease, Serine protease |
| Biological process | Cell adhesion |
Function
Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.