IQGAP2 — IQ motif containing GTPase activating protein 2
IQGAP2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IQGAP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | WNT4+ Stromal Fibroblast Developmental | CARD16, CASP1, FBLIM1, FHL2, GRK5, OTULINL, PIEZO2, PROCR +7 more | View in SCUBA |
| Gamma-delta T cells | Innate Stress Signaling Inflammation | AKT3, B4GALT4, BCR, BLOC1S4, COL6A2, CREBRF, DGKQ, ELF2 +23 more | |
| Glial cells | Neural Migration Scaffold Cytoskeletal | ABLIM1, ALCAM, ANK3, CAB39L, GAS2L3, GFRA3, NRXN1, RELN +1 more | View in SCUBA |
| Hematopoietic progenitor cells | Megakaryocyte IFN-primed Inflammatory | COL24A1, ELK3, GBP4, GUCY1A1, HLA-E, IFI16, MAML2, MYO5C +2 more | |
| Innate lymphoid cells | Cytoskeletal Remodeling Cytoskeleton & motility | BCLAF1, BPTF, CBL, CDK13, KDM2A, KDM5A, LTC4S, MACF1 +8 more | View in SCUBA |
| Mucosal-associated invariant T cell | Calcineurin-NFAT Signaling TCR Signaling | AKT3, CDC14A, NCALD, NEK7, PLCB1, PLCL2, PPP2R2B, PPP3CA +3 more | |
| Neutrophils | Granulopoiesis Program Developmental | ARHGAP24, ARID1B, B4GALT5, CSGALNACT1, FLI1, LYST, PDZD8, PHIP +5 more |
About the gene
| Chromosome | 5: 76403285-76708132 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Calmodulin-binding |
Function
Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.