Neural Migration Scaffold
Gene co-expression module in Glial cells
| Category | Cytoskeletal |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
RELN encodes Reelin, a large secreted ECM glycoprotein critical for neural cell migration and positioning, expressed by enteric glia and interneurons. ANK3 (ankyrin-G) scaffolds membrane proteins to the spectrin-actin cytoskeleton, critical for axon initial segments and nodes of Ranvier. ABLIM1 is an actin-binding LIM protein expressed in neural tissues. IQGAP2 organizes cytoskeletal signaling. ALCAM (CD166) is a neural cell adhesion molecule. NRXN1 (neurexin-1) is a presynaptic adhesion molecule critical for synapse organization. GFRA3 is a GDNF family receptor alpha-3 expressed in enteric neurons/glia, mediating neurotrophic signaling. CAB39L activates AMPK. GAS2L3 is involved in cytoskeletal regulation. XKR4 is a scramblase. The module emphasizes glial-neuronal cytoskeletal scaffolding and neural migration/adhesion programs, significantly lost in UC inflammation.
Genes
ABLIM1, ALCAM, ANK3, CAB39L, GAS2L3, GFRA3, IQGAP2, NRXN1, RELN, XKR4
Most correlated modules
- Matricellular ECM Homeostasis · correlation 0.95
- Glial Adhesion Cytoskeletal · correlation 0.91
- Glial Synaptic Adhesion · correlation 0.82
- Neuroprotective Secretory · correlation 0.80
- Glial Myelination Identity · correlation 0.78
- Myelinating Schwann Cell · correlation 0.76
- Glial Homeostatic Identity · correlation 0.75
- Peripheral Nerve Myelination · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.