OSGEP — O-sialoglycoprotein endopeptidase
OSGEP belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OSGEP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Transcription RNA Processing RNA processing & translation | ARMCX6, BANF1, CCAR1, CLDND1, COMMD1, FEZ2, HELZ, HSBP1 +11 more | View in SCUBA |
About the gene
| Synonyms | GCPL1, KAE1, OSGEP1, PRSMG1, TCS3 |
|---|---|
| Chromosome | 14: 20446401-20455089 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Acyltransferase, Transferase |
| Biological process | tRNA processing |
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.