CCAR1 — Cell division cycle and apoptosis regulator 1
CCAR1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCAR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | DNA Damage Response DNA/chromatin regulation | AP1B1, CHD8, DOCK2, EP400, ERBIN, GOLM2, IPO8, LRBA +17 more | |
| Goblet cells | Chromatin Remodeling chromatin regulation & transcription | ENAH, FNBP1L, KDM1A, LMO4, PAIP1, PBRM1, RHOBTB3, RTF1 +2 more | View in SCUBA |
| Innate lymphoid cells | Transcription RNA Processing RNA processing & translation | ARMCX6, BANF1, CLDND1, COMMD1, FEZ2, HELZ, HSBP1, IRF2 +11 more | View in SCUBA |
| Macrophages | RNA Processing Housekeeping Housekeeping | BAZ1A, BDP1, CCDC88A, CLIP1, CUL5, DHX36, DNM1L, EP400 +32 more | View in SCUBA |
About the gene
| Synonyms | CARP-1, CARP1, FLJ10590 |
|---|---|
| Chromosome | 10: 68721012-68792377 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Predicted intracellular proteins |
| Molecular function | Activator, Repressor |
| Biological process | Apoptosis, Cell cycle, Transcription, Transcription regulation |
Function
Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.