SCUBA

HSBP1 — Heat shock factor binding protein 1

HSBP1 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HSBP1's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsProteasome translation
Housekeeping
ADRM1, CD2BP2, CDV3, CST7, EHBP1L1, EIF3J, ENO1, MAPKAPK2 +5 moreView in SCUBA
CD8⁺ T cellsProteasome Degradation
Housekeeping
ARPP19, CLTA, GNG5, NDUFB4, POLR2J, POLR2K, PSMB2, PSMB3 +2 moreView in SCUBA
EndothelialRespiratory Chain Complex
Mitochondrial & OxPhos
ATP5MG, CHCHD2, MTCH2, NDUFB11, NDUFS8, NDUFV2, SNRPD2, UQCR10View in SCUBA
FibroblastsRho GTPase Cytoskeletal
Cytoskeletal
APRT, CLIC1, CYBA, LY6E, RAB34, RHOA, RHOC, S100A11 +2 moreView in SCUBA
Glial cellsAntioxidant Stress Response
Stress
AP2S1, CSTB, DYNLRB1, MAGED2, NDUFB11, PLPP1, PPDPF, SELENOW +1 moreView in SCUBA
Goblet cellsProteasome Complex
Protein processing & ER
DSTN, GNG5, NDUFA4, PCBD1, PPP1CA, PSMA3, PSMB2, PSMB5 +1 moreView in SCUBA
Innate lymphoid cellsTranscription RNA Processing
RNA processing & translation
ARMCX6, BANF1, CCAR1, CLDND1, COMMD1, FEZ2, HELZ, IRF2 +11 moreView in SCUBA
MacrophagesProtein Homeostasis Mixed
Housekeeping
ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 moreView in SCUBA
PericytesER Chaperone UPR
Stress
CALR, HSP90B1, PDIA3, PDIA6, PSMB5, RAB13, SSR4View in SCUBA
Smooth muscle cellsSMC focal adhesion
Migration & adhesion
ANXA6, ARMCX6, C1orf21, CD99, DNAJC1, KANK1, MORF4L2, PFDN1 +7 moreView in SCUBA

About the gene

Chromosome16: 83719311-83819737
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins

Function

Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.