Transcription RNA Processing
Gene co-expression module in Innate lymphoid cells
| Category | RNA processing & translation |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include HELZ (RNA helicase, mRNA decay/translation regulation), HSBP1 (heat shock factor binding protein, HSF1 inhibitor), SRSF11 (serine/arginine splicing factor), POLR2H (RNA polymerase II subunit), BANF1 (barrier-to-autointegration factor, nuclear envelope/chromatin organization), LSM7 (Sm-like protein, snRNA/mRNA processing), PRPF38A (pre-mRNA splicing factor), IRF2 (interferon regulatory factor 2, transcription repressor), CCAR1 (cell cycle and apoptosis regulator). The convergence of splicing factors (SRSF11, LSM7, PRPF38A), RNA helicase (HELZ), and RNA Pol II subunit (POLR2H) points to a transcription/RNA processing program. HSBP1 adds a stress-response dimension. Moderate coherence with mostly weak memberships. Neighbors share RNA processing themes (M19).
Genes
ARMCX6, BANF1, CCAR1, CLDND1, COMMD1, FEZ2, HELZ, HSBP1, IRF2, LSM7, OSGEP, PIH1D1, POLR2H, PRPF38A, RNH1, SCAMP2, SELENOW, SNAP29, SRSF11, TMED4
Most correlated modules
- Actin Cytoskeleton Dynamics · correlation 0.92
- Mitochondrial Translation · correlation 0.92
- RNA Chromatin Regulation · correlation 0.92
- Transcriptional Regulation · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.