PAPPA — Pappalysin 1
PAPPA belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PAPPA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Inflammatory Cytokine Signaling Inflammation | BACH1, BTG3, CSF1, FSTL3, NNMT, PDPN, RAB13, STK17A +3 more | View in SCUBA |
About the gene
| Synonyms | ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1 |
|---|---|
| Chromosome | 9: 116153791-116402321 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
Function
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.