FSTL3 — Follistatin like 3
FSTL3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FSTL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Inflammatory Cytokine Signaling Inflammation | BACH1, BTG3, CSF1, NNMT, PAPPA, PDPN, RAB13, STK17A +3 more | View in SCUBA |
| Smooth muscle cells | Mesenchymal Adhesion Program Migration & adhesion | ANTXR1, BAG2, CDH11, COL12A1, CTSB, FHL3, HEPH, PIM1 +6 more | View in SCUBA |
About the gene
| Synonyms | FLRG, FSRP |
|---|---|
| Chromosome | 19: 676392-683392 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Osteogenesis, Transcription, Transcription regulation |
Function
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.