NNMT — Nicotinamide N-methyltransferase
NNMT belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NNMT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ER Stress UPR Stress | ARF4, B4GALT1, BTG3, BZW1, CYCS, EFHD2, ELOC, LDHA +6 more | View in SCUBA |
| Glial cells | Inflammatory Cytokine Signaling Inflammation | BACH1, BTG3, CSF1, FSTL3, PAPPA, PDPN, RAB13, STK17A +3 more | View in SCUBA |
| Pericytes | Inflammatory Pericyte Activation Developmental | CDH11, CHN1, EGFL6, PROCR, PRRX1, SERPINF1, TDO2, TYMP | View in SCUBA |
| Smooth muscle cells | Activated Myofibroblast Activation | CNN3, EPHX1, IFI16, IGFBP4, LAPTM4B, SERPING1, SSR4, SULF1 +3 more | View in SCUBA |
About the gene
| Chromosome | 11: 114257787-114313536 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Methyltransferase, Transferase |
Function
Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1- methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway. Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3. In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state. Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (By similarity). Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (By similarity). Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.