RAB13 — RAB13, member RAS oncogene family
RAB13 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAB13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Hypoxia Response Stress | C1orf122, CRELD2, CSTB, EFHD2, FKBP1A, HIF1A, LAPTM4B, NECTIN2 +3 more | View in SCUBA |
| Fibroblasts | Complement-secreting Fibroblast Immune interaction | ADI1, ARL6IP5, C1R, C2, CYB5A, FCGRT, FTH1, FTL +9 more | View in SCUBA |
| Glial cells | Inflammatory Cytokine Signaling Inflammation | BACH1, BTG3, CSF1, FSTL3, NNMT, PAPPA, PDPN, STK17A +3 more | View in SCUBA |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ANPEP, AQP9, CD300E, CD82, CLEC5A, CXXC5, DDX60L, DHRS9 +25 more | View in SCUBA |
| Monocytes | Integrin-mediated Migration Migration & adhesion | DNAAF1, EIF4E, ITGA5, ITGB8, LMNA, MSC, NRIP3, PHLDA1 +7 more | View in SCUBA |
| Pericytes | ER Chaperone UPR Stress | CALR, HSBP1, HSP90B1, PDIA3, PDIA6, PSMB5, SSR4 | View in SCUBA |
| Smooth muscle cells | Vascular Matrix Secretion ECM remodeling | ARPC1B, BGN, CALHM2, HSPB7, MGP, MXI1, TRIM47 | View in SCUBA |
About the gene
| Chromosome | 1: 153981617-153986358 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Protein transport, Transport |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.