Inflammatory Cytokine Signaling
Gene co-expression module in Glial cells
| Category | Inflammation |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes: CSF1 (colony-stimulating factor 1, macrophage recruitment cytokine), UGCG (ceramide glycosylation, sphingolipid stress response), PAPPA (metalloprotease, IGF bioavailability), BTG3 (anti-proliferative, stress response), BACH1 (transcription factor, oxidative stress), PDPN (podoplanin, lymphatic/stromal marker), FSTL3 (TGF-beta/activin antagonist), TNFRSF12A (TWEAKR, NF-kB activation), TNFAIP6 (hyaluronan binding, anti-inflammatory matrix), NNMT (nicotinamide methyltransferase, fibroblast activation), STK17A (DRAK2, apoptosis/stress kinase), RAB13 (vesicle trafficking). Very high inflammation delta (UC: 0.766). CSF1, TNFRSF12A, TNFAIP6, PDPN, FSTL3, and NNMT collectively point to a stromal/glial inflammatory activation state driving immune cell recruitment and paracrine signaling. BACH1 and BTG3 indicate a stress/redox regulatory overlay. This module resembles an inflammatory cytokine/paracrine signaling program in activated glia, promoting macrophage recruitment (CSF1) and modulating the ECM microenvironment (TNFAIP6, PDPN).
Genes
BACH1, BTG3, CSF1, FSTL3, NNMT, PAPPA, PDPN, RAB13, STK17A, TNFAIP6, TNFRSF12A, UGCG
Most correlated modules
- ER Stress Response · correlation 0.84
- NF-κB/IFN Inflammatory · correlation 0.84
- Proteostasis Stress Response · correlation 0.82
- RNA Translation Processing · correlation 0.81
- IFN-gamma Effector Program · correlation 0.78
- COX-2/NF-κB Inflammation · correlation 0.77
- Proteostasis Stress Response · correlation 0.76
- Reactive Glial Activation · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.