PC — Pyruvate carboxylase
PC belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Inflamed Barrier Remodeling Inflammation | ABHD2, AKIRIN2, CAPN8, CD55, CLDN12, EPB41L2, INPP1, ITGA6 +17 more | View in SCUBA |
About the gene
| Synonyms | PCB |
|---|---|
| Chromosome | 11: 66848417-66958386 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Citric acid cycle related proteins, Disease related genes, Enzymes, Essential proteins, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Ligase, Multifunctional enzyme |
| Biological process | Gluconeogenesis, Lipid biosynthesis, Lipid metabolism |
Function
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.