SCUBA

ITGA6 — Integrin subunit alpha 6

ITGA6 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ITGA6's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsNaive T quiescence
T cell development		CCR7, CD55, CRIP2, CSGALNACT1, KLF2, KLF3, NOSIP, RASA3 +6 moreView in SCUBA
EndothelialVenous Endothelial Identity
Endothelial cell development		ABI3, CCDC85B, DOCK4, EHD4, EVA1B, EXOC3L2, HDAC7, MCF2L +8 moreView in SCUBA
EnterocytesBasal adhesion remodeling
Migration & adhesion		EPB41L2, ETS2, FNDC3B, HERC4, NT5C2, SESTD1, SGMS1, SH3RF1 +2 moreView in SCUBA
Gamma-delta T cellsNaïve T Cell State
T cell maturation		ARL14EP, CCR2, CD27, CD28, CD40LG, CD82, CNN2, CPNE2 +19 more
Lymphatic endothelialCollecting Lymphatic Identity
migration & adhesion		CCDC141, EFNB2, EPB41, FBXO34, FGD6, GUCY1A1, MDFIC, NAV1 +13 moreView in SCUBA
MacrophagesFc Receptor Phagocytosis
Lysosomal & pahgocytosis		ANXA6, C1orf162, CD37, FCGR1A, FCGR3A, FPR1, GCA, HNMT +10 moreView in SCUBA
Mucosal-associated invariant T cellMature Effector MAIT
T cell maturation		ADD3, ANTKMT, APOBEC3G, CCL5, CXXC5, FHL3, GZMK, ITGB2 +7 more
PericytesVascular Permeability
Migration & adhesion		ABI3, FLT1, GALNT18, NQO1, PLVAP, PRKCH, TM4SF18View in SCUBA

About the gene

SynonymsCD49f
Chromosome2: 172427354-172506459
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classCancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Molecular functionIntegrin, Receptor
Biological processCell adhesion

Function

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.