CAPN8 — Calpain 8
CAPN8 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CAPN8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Inflammatory goblet response Immune function | ANXA1, B4GALT1, CEACAM6, DST, KRT20, LYPD8, MUC13, MXD1 +8 more | View in SCUBA |
About the gene
| Synonyms | nCL-2 |
|---|---|
| Chromosome | 1: 223538007-223665723 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, Thiol protease |
Function
Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.